J Fraser Wright Selected Research

Retinaldehyde (Retinal)

1/2018	Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.
8/2016	Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial.
3/2010	Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.
11/2009	Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial.
5/2008	Safety and efficacy of gene transfer for Leber's congenital amaurosis.

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J Fraser Wright Research Topics

Disease

7	Hemophilia A (Haemophilia) 12/2017 - 09/2003
6	Hemophilia B (Haemophilia B) 12/2017 - 03/2006
4	Blindness (Hysterical Blindness) 01/2019 - 11/2009
3	Body Weight (Weight, Body) 01/2021 - 04/2013
2	Infections 01/2022 - 03/2012
2	Inflammation (Inflammations) 01/2021 - 01/2018
2	Neoplasms (Cancer) 04/2016 - 03/2011
2	Experimental Arthritis 06/2015 - 01/2015
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2021
1	Hyperplasia 01/2021
1	Photophobia (Light Sensitivity) 01/2019
1	HIV Infections (HIV Infection) 01/2019
1	Retinoschisis (Retinoschisis, Juvenile) 01/2018
1	Retinal Detachment (Retinal Detachments) 01/2018
1	Hemorrhage 12/2017
1	Epilepsy (Aura) 08/2017
1	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 04/2016
1	Hematologic Neoplasms (Hematological Malignancy) 04/2016
1	Arthritis (Polyarthritis) 01/2015
1	Rheumatoid Arthritis 01/2015
1	Nervous System Diseases (Neurological Disorders) 10/2014
1	Thrombotic Thrombocytopenic Purpura 05/2013
1	Thrombocytopenia (Thrombopenia) 05/2013
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2013
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 04/2013
1	Leukemia 04/2013
1	Cytokine Release Syndrome 04/2013
1	Chronic Hepatitis C 03/2012
1	Leber Congenital Amaurosis 10/2010
1	Liver Diseases (Liver Disease) 06/2010
1	Retinal Diseases 03/2010
1	Retinal Perforations 05/2008

Drug/Important Bio-Agent (IBA)

6	Factor IX (Coagulation Factor IX)FDA LinkGeneric 12/2017 - 03/2006
5	Retinaldehyde (Retinal)IBA 01/2018 - 05/2008
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2003
3	Factor VIII (Coagulation Factor VIII)IBA 01/2014 - 09/2003
2	Biological ProductsIBA 01/2021 - 03/2012
2	Blood Coagulation Factors (Coagulation Factor)IBA 12/2017 - 01/2016
2	Chimeric Antigen ReceptorsIBA 04/2016 - 04/2013
2	InterferonsIBA 06/2015 - 01/2015
2	Interferon-betaIBA 06/2015 - 01/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 03/2011
2	CytokinesIBA 01/2015 - 04/2013
1	CRISPR-Cas Systems Guide RNAIBA 01/2022
1	Calcitonin Gene-Related PeptideIBA 01/2021
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2021
1	GlobinsIBA 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018
1	factor IX-PaduaIBA 12/2017
1	CoagulantsIBA 12/2017
1	prothrombin complex concentrates (PPSB)IBA 12/2017
1	CatecholaminesIBA 10/2014
1	Aromatic-L-Amino-Acid DecarboxylasesIBA 10/2014
1	Serotonin (5 Hydroxytryptamine)IBA 10/2014
1	Shiga Toxin (Shigella Toxin)IBA 05/2013
1	thiamine triphosphorate (TTP)IBA 05/2013
1	von Willebrand FactorIBA 05/2013
1	tocilizumab (atlizumab)FDA Link 04/2013
1	Etanercept (Enbrel)FDA Link 04/2013
1	tisagenlecleucelIBA 04/2013
1	CTL019 chimeric antigen receptorIBA 04/2013
1	Neutralizing AntibodiesIBA 07/2012
1	AntibodiesIBA 07/2012
1	Antiviral Agents (Antivirals)IBA 03/2012
1	CytosineIBA 03/2011
1	Phosphates (Orthophosphate)IBA 03/2011
1	GuanosineIBA 03/2011
1	Retinal Pigments (Pigments, Visual)IBA 10/2010

Therapy/Procedure

10	Therapeutics 01/2021 - 01/2009
1	Intramuscular Injections 01/2019
1	Oral Surgery (Maxillofacial Surgery) 08/2017
1	Immunotherapy 04/2016
1	Intra-Articular Injections 06/2015